I met Dr. Bruce Tromberg a few years ago during a visit I made to UC Irvine. Besides being impressed with the gorgeous campus in Southern California, I was able to see his laboratory and meet with several of the students, postdocs, and research technicians he worked with. As an expert in diffuse optical spectroscopy (DOS), he told me how the use of multiple optical contrast elements such as absorption, scattering, fluorescence, and speckle can be used to measure various optical and physiological properties such as blood flow, vascular density, extracellular matrix composition, and cellular metabolism. Specifically, DOS uses spatially- and temporally-modulated sources and model-based analyses to produce dynamic in vivo functional imaging with variable spatial localization. His clinical work has focused on the use of broadband DOS to measure breast tumor metabolism with sufficient sensitivity for cancer detection and therapeutic drug monitoring. Broadband spatial frequency-domain imaging is also used in animal models to dynamically map intrinsic brain signals, monitor the efficacy of chemotherapeutic agents, and form depth-resolved tomographic images of fluorescence and hemodynamics. Dr. Tromberg is giving a plenary talk at 8am on Tuesday (5/1) that is titled, "Diffuse Optical Spectroscopy: Technology Development and Clinical Translation." It should be a great talk for those interested in the current and future role of diffuse optics in medical imaging!
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