I recently spoke with David Nolte, a Professor in Physics at Purdue University, about his work using holographic optical coherence imaging (HOCI) to quantify subcellular motion from deep within living tissue. His group has developed this relatively new imaging technique that uses cellular motility as a novel contrast agent. Data can be obtained from up to 1mm within tissue - a range most microscopic imaging methods cannot reach. I was impressed that this technique can be directly applied to a variety of biomedical applications, including monitoring the cytoskeletal response to drug candidates. Dr. Nolte's talk on Sunday (4/29) from 3:30-4:00pm in Concerto D is titled "Digital Holography of Cellular Motions in Live Tissue" and should be of great interest to those interested in digital holography and its use in drug screening.
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